Portal is Developing a Universal Cell Engineering Solution

Portal’s proprietary membrane technology uses mechanical disruption and enables massive parallelization

What can Portal enable for you?

A Snapshot of Portal by our Partners at Bayer

Explore our publications

Pick your cell and cargo to see the data

All Cells

All Cargos

Publication · 2022 · FRONTIERS IN IMMUNOLOGY

Engineered Red Blood Cells (Activating Antigen Carriers) Drive Potent T Cell Responses and Tumor Regression in Mice

Katarina Blagovic, Carolyne K. Smith, Amritha Ramakrishnan, Lindsay Moore, David R. Soto, Zachary Thompson, Adam P. Stockmann, Sonia Kruszelnicki, Akshi Thakkar, Jason Murray, Sebastian Torres, Bersabel Wondimagegnhu, Roslyn Yi, Maisam Dadgar, Abdul M. Paracha, Claire Page, Louise Clear, Omer A. Chaudhry, Melissa Myint, Devin T. Bridgen, Jonathan B. Gilbert, Katherine J. Seidl, Armon Sharei, Scott Loughhead, Howard Bernstein, and Defne Yarar

Download

Publication · 2022 · ESMO IMMUNO-ONCOLOGY AND TECHNOLOGY

Cell Squeeze®: Driving more effective CD8 T cell activation through cytosolic antigen delivery

Jong Chul Park, Howard Bernstein, Scott Loughhead, Ricardo Zwirtes, Julia

Jennings, Valeria Nicolini, Christian Klein, Laura Codarri Deak, Pablo Umana,

Christine Trumpfheller, Armon Sharei

Download

Publication · 2022 · FRONTIERS IN IMMUNOLOGY

Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes

Colin J. Raposo, Judith D. Cserny, Gloria Serena, Jonathan N. Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, and Shinu John

Download

Publication · 2022 · JOURNAL OF IMMUNOLOGY

Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

Matthew G. Booty, Kelan A. Hlavaty, Adam Stockmann, Howard Bernstein, Armon Sharei, Scott M. Loughhead, Hendrik Knoetgen, Christine Trumpfheller, Pablo Umaña, Ulrich H. von Andrian, Klavs F. Jensen, Robert Langer, Jacques, Eritza Chong, Lucas Pomerance, John T. Gonzalez, Shirley Mao, Megan Heimann, LeeAnn Talarico, Miye K. Jonathan Chow, Tarek Abdeljawad, Harry An, Sophia Liu, Vicente-Suarez, Defne Yarar, Melissa Myint, Amy Merino, Olivia Pryor, Kelly Volk, Katarina Blagovic, Ildefonso, Disha Subramanya, Anita Venkitaraman, Christian Yee, Emrah Ilker Ozay, Carolyne Smith, Lina Tian, Edylle How

Download

Portal News

Businesswire • Press Release

Portal Biotechnologies Awarded $8M DARPA Contract to Increase Access to Cell Therapy via a Portable, Red Blood Cell Engineering Device for Rapid Point-of-Care Production and Treatment

Portal’s collaboration with DARPA’s “Red Blood Cell (RBC) Factory” program aims to develop a portable, field-deployable, personalized and scalable cell therapy device that enables diverse cargo...

Businesswire • Press Release

Portal Biotechnologies Announces Over 50 Partnerships and Oversubscribed $7M Seed Round Led by IA Ventures

Rapid platform adoption with over 50 biopharma and academic partners to date, including 7 of the top 10 pharmaceutical companies Oversubscribed $7M financing proceeds, coupled with revenue, to drive...

Boston Business Journal • Media

Founder of SQZ is back with new startup focused on cell therapies

A year after leaving the company he founded, SQZ Biotechnologies, Armon Sharei has a new venture that has a similar approach to getting stuff inside cells.