Portal’s Universal Delivery Platform Unlocks Novel Workflows

Simple, high throughput mechanical delivery technology. Used standalone or integrated into existing equipment.

Intracellular Delivery is Critical to Many Research and Clinical Applications

The Portal Advantage

Portal excels where others struggle, enabling cytosolic access for diverse cell types and cargoes.

Status Quo

With Portal

How it Works

Portal’s technology enables diverse and multiplexed delivery into cells via a simple diffusion mechanism.

Boost any cargo into any cell, and unlock novel assays and next-gen cell therapies.

What Portal's Technology Does Differently

Portal allows you to answers question directly inside your cell, and design it for any function you need. Check out all kinds of benefits!

No vector, no pulse, no carrier

A physical squeeze does the work, so delivery does not depend on the chemistry of the cargo.

Gentle on the cell

Cells keep their phenotype and function, with no electrical or lipid damage.

Works across cells and cargo

Proteins, RNPs, mRNA, peptides, degraders, and impermeable compounds, across primary cells and lines.

Bench to GMP

The same method from a benchtop run to more than a billion cells a minute.

No vector, no pulse, no carrier

A physical squeeze does the work, so delivery does not depend on the chemistry of the cargo.

Gentle on the cell

Cells keep their phenotype and function, with no electrical or lipid damage.

Works across cells and cargo

Proteins, RNPs, mRNA, peptides, degraders, and impermeable compounds, across primary cells and lines.

Bench to GMP

The same method from a benchtop run to more than a billion cells a minute.

Proven in partner labs

Groups at pharma and academic labs put Portal's platform to work on their own cells and cargo. Each talk below walks through what the team ran and what they found.

WEBINAR

Merck: Degrader permeability without a stable cell line

Merck's discovery group reads degrader permeability and target engagement by boosting the reporter straight into their own cells, rather than building and maintaining a stable line for every target. Delivering a VHL-NanoLuc reporter into AsPC-1 cells lets the team measure degrader activity and kinetics in the relevant cell background, and a p53/MDM2 peptide assay in HCT116 on an automation-integrated Galaxy returns high viability and delivery.

Watch the Webinar

WEBINAR

ABBVIE Rescuing compounds that read as inactive

AbbVie's Small Molecule Therapeutics and Platform Technologies group shows how permeability can hide real compounds, turning active ones into false negatives in a standard assay. Boosting impermeable compounds directly into the cytosol recovers activity that passive uptake misses, including a BRD4 degrader that moves from 82% to 50% protein remaining, while permeable controls behave the same with or without a boost.

Watch the Webinar

Portal technology has been integrated with your favorite tool providers

Products

Gateway

Research Scale

Benchtop instrument for discovery research

0.5-10M cells per run

50-200 µl volume range

compact benchtop unit that fits in any hood

Available now

Galaxy-i

High-Throughput Screening

High throughput scale instrument for screening applications with multi well plates.

96/384-well plate compatibility

Integrate with existing automation

Ideal for DEL, PROTAC, crispr screening

Available now

Millibooster

Clinical Manufacturing

GMP-ready clinical production system

1 billion+ cells/minute throughput

Attach to existing equipment via tube-weld or luer lock connection

2-100mL volume range

Available now

Portal Kits

Validated Workflows

Ready to use kits for every assay

Complete workflows, ready to run.

MicroBooster™ cartridges

Optional white-glove support

Available now

What can Portal enable for you?

Portal enables lots of new, non-obvious applications. Tell us about your work, and we'll give you some suggestions! (Remember AI tools say dumb things sometimes, talking to our team of humans is always best)

Want to try out our technology for yourself?

Tell us about your work and a Portal scientist will share how we can support it.