Publications

Publication · 2026 · bioRxiv

Mechanically-mediated low-pressure cell membrane poration enables tunable intracellular delivery of traditionally impermeable cargoes in high throughput and clinical scale formats

Sophia M. Hirsch, Darby Kreienberg, Zhihui Song, Andrew Larocque, Yi Zuo, Rachel Conover, Eleni Jaecklein, Karen Gonzalez, Ain Imchen, Sean Franco, Michael A. Evans, R. Alexander Wesselhoeft, Matthew R. Swiatnicki, Hicham Zegzouti, Kirill Chesnov, Marius Wernig, Neil S. Dhawan, Cameron Pye, Scott M. Loughhead, Jacquelyn L. Sikora Hanson, Alec Barclay, Armon Sharei

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Presentation · 2025 · Deep Tech Global Summit

Ridiculously simple, scalable cell engineering

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Poster · 2025 · Keystone Symposia: Proximity based Therapuetics: Targeted protein degradation

Accelerating Discovery by Unlocking Novel Live Cell Assays with a Silicon Membrane-based Platform for Mechanical Delivery of Impermeable Small Molecules, Peptides, and Probes

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Poster · 2025 · Keystone Symposia: Cancer Immunotherapy/Immune Cell Therapies

A next generation immune cell engineering platform to generate multifunctional cells using a silicon membrane-based delivery system

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Poster · 2025 · AACR

Combining circular RNA and a silicon membrane-based cell engineering approach to create CAR-Ts with membrane bound IL-2 and IL-12

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Poster · 2025 · SLAS (Europe)

Enabling novel live cell assays with a silicon membrane-based platform for mechanical delivery of impermeable small molecules, peptides, and probes to accelerate early drug discovery

Anil Narasimha, Sophia Hirsch, Darby Kreienberg, Andrew Larocque, Eleni Rogers, Zhihui Song, Xi Ai, James Vasta, Matthew Robers, Alec Barclay, Armon Sharei

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