High Throughput Intracellular Delivery with Galaxy-i

Next-generation mechanoporation platform enabling scalable, automated cell engineering from bench top to large library screening. Process thousands of samples with unprecedented precision and efficiency

Three Integration Options

Choose the configuration that matches your throughput needs, from core research to full clinical production

Galaxy

High-throughput device for mechanoporation on liquid handler deck. Offers maximum flexibility for liquid handlers. Mechanoporates cells and outputs into a trough ready for liquid handler.

No special software or integrations required
2–50ml
1–100M/ml cells
Compatible with both manual workflows and liquid handlers

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Galaxy-i Single Dispenser

Offers automated dispensing into multiwell plates. Integrates into fluidics of existing robots and mechanoporates cells immediately before dispensing.

Minimizes time between boosting and plating on cargo
Consistent performance across device
Dispense time per plate remains the same
Minimal modifications of existing systems

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Galaxy-i Eight Dispensers

Offers automated dispensing into multiwell plates at higher throughput. Integrates into fluidics of existing robots across all eight channels.

Minimizes time between boosting and plating on cargo
Consistent performance across device
Dispense time per plate remains the same
Minimal modifications of existing systems
8X the throughput

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Portal Unlocks Novel Drug Discovery Opportunities

Hit Identification

Direct intracellular access for poorly permeable molecules . Use the drug screening cell cartoon

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Assay Reagent Delivery

Impermeable tagged probes, proteins, and antibodies

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Primary Cell Assays

Gene edit or modulate primary cells for assays

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Direct to Biology Assays

intracellular delivery of DEL libraries

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HT Primary Cell CRISPR Screens

Conduct large library crispr screening

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How Does HT Mechanoporation Work?

Our Galaxy systems work by boosting cells as they transit through the membrane onto plates with pre-plated cargo where they then take up the material

How It Works

This works because after boosting the pores in the cell membrane remain open for approximately 30 seconds. During this brief window, cells are dispensed directly onto plates with pre-plated cargo, enabling efficient uptake of materials.

Key Advantages

Pre-loaded plates: prepare cargo libraries in standard plates ahead of time
On-demand processing: Add cells and process when ready – no wait time for cargo prep
Multi-cargo flexibility: Different payloads per well for screening

Critical Timing Window

Cell membrane pores remain open for 5–30 seconds post-boosting, allowing efficient cargo uptake when cells are dispensed onto pre-plated material. This brief window enables high-throughput processing while maintaining cell viability and function.

Platform Validation Data

Primary Cell Crispr Screening

Demonstrated proof-of-concept for CRISPR screening in primary cells using the Galaxy-i with Certus Flex. This workflow achieved successful B2M RNP delivery to primary T cells in a high-throughput system—enabling functional genomics applications in clinically relevant cell types.

Consistent Delivery Across Plates

Validated consistent delivery performance in HeLa cells across five 96-well plates using diverse cargo types: 3kDa dextran, labeled oligo, and IgG antibody—demonstrating platform reliability across molecular sizes and formats.

Broad Cell Type Compatibility

Demonstrated successful delivery across multiple cell types, including HEK293 cells (oligo & antibody) and human peripheral blood mononuclear cells (PBMCs shown here)—critical for drug discovery programs that require validation across diverse cell models.

Complex Cargo Delivery

Achieved high GFP mRNA transfection efficiency in HeLa cells while preserving cell viability—demonstrating the platform's capability for delivering large, complex cargos essential for gene editing, regulatory RNA studies, and functional genomics screening.

What Does an Integration Look Like?

Modular physical integration – connects to your automation platform without permanent modifications

Nnano/Gyger

Certus Flex

HighRes

PrecisionDrop II

GNF System

Integra
Welljet

Seem Interesting? Get Boosting!