Portal Kits

Simple kits to do everything from altering cell function to providing insights on intracellular biochemical interactions.

Every kit includes: Cell-modifying cargoes · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

How the kits work

Every Portal kit runs the same five steps. The cargo and the readout change from kit to kit. The boost stays the same.

Isolate / Prepare

Your cells: primary, stem, or a cell line

Mix

Cells + cargo (RNA / RNP / antibody / library)

Boost

Gateway™ cartridge

Reset / Express

Cargo acts or expresses within hours

Assay

Function, expression, or screen readout

Cell Engineering Kits

Validated cell engineering workflows, a one stop shop.

Every kit includes: Cell-modifying cargoes · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

CELL THERAPY

T Cell Functional Enhancement

Best suited for: Human T cells (activated or unstimulated), PBMCs
Available enhancements: mbIL2, mbIL12, Perforin, Gzmb, B2M and TCR knockouts
Measure endogenous intracellular proteins in live cells
Use cases: Cytokine armoring, gene KO, persistence enhancement

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STEM CELL BIOLOGY

iPSC Generation

Best suited for: PBMCs & fibroblasts
Available enhancements: Oct4, Sox2, Klf4, cMyc RNA
Best suited for: Reprogramming, disease modeling

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IMMUNOLOGY

APC Enhancement

Best suited for: PBMCs, dendritic cells
Available enhancements: mbIL2, mbIL12, CD86, custom antigen RNA
Best suited for: Immune activation, DC engineering, vaccine research

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Stem cell biology

HSC Enhancement

Best suited for: Hematopoietic stem cells
Available enhancements: CXCR4, BCL2
Best suited for: Engraftment, survival, stemness preservation

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NEUROSCIENCE

Neuronal Differentiation

Best suited for: iPSC-derived neurons, neural progenitors
Available enhancements: NGN2, ASCL1, LMX1A, FOXA2, NURR1, ASOs
Best suited for: Neuronal differentiation, disease modeling, Parkinson's/ALS

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Drug Discovery Kits

Validated live-cell workflows for target engagement, compound profiling, and beyond.

Every kit includes: Cargoes · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

Impermeable Candidate Validation in Live Cells

Solves: Permeability engineering as a prerequisite for testing cellular activity
Cargo: Your impermeable drug candidate
Validate and test your candidates in live cells, regardless of permeability
e.g. small molecules, macrocycles, peptides

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Live-Cell Protein Detection

Solves: Live-cell context lost to lysis, and target labeling that requires cell engineering.
Cargo: Intracellular antibodies (primary & secondary)
Measure endogenous intracellular proteins in live cells
e.g. p-BTK, p-ERK, p-AKT, p-STAT3, p-MET Compatible with LgBiT/HgBiT reagents

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Live-Cell Target Engagement

Solves: Live-cell context lost to lysis and detergents, and the need to create cell-permeable tracers
Cargoes: Your tracers (e.g. NanoBRET) and compounds
Enables live-cell target engagement without lysis; supports impermeable tracers
e.g. kinase inhibitor profiling, degrader engagement

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Controllable Surface Antigen Expression

Solves: Fixed, hard-to-modulate surface antigen expression in cell lines
Cargo: Custom antigen/receptor RNA — single or combinations
Express any antigen on any cell in hours
e.g. CD19+CD3, BCMA+CD3, HER2+CD3

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Direct-to-Assay

Solves: The stable-line bottleneck: infeasible in primary cells, slow and laborious elsewhere
Cargo: Custom RNA encoding tagged POI
Run NanoBRET or LgBiT/HgBiT without stable lines
e.g. VHL-NanoLuc, HgBiT-tagged POI, HA-tagged POI

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Intracellular DEL Screening

Solves: DEL screens can't be done in live human cells
Cargo: Your DEL library
Screen intracellular targets with no library bias
e.g. iPSCs, HeLa, PBMCs — any cell type

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What Every Kit Includes

A kit is more than reagents. It's the cargo, protocol, MicroBooster™ cartridges, and suggested readouts. Everything to go from the bench to real data in one workflow.