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DELs in Cells: The Krusemark Lab Expands Portal's Capabilities

DNA-encoded chemical libraries are screened against purified protein outside of cells. Portal changes that — delivering full DEL constructs directly into the cytoplasm of live cells, so selections can run against targets in their native environment.

What You'll Learn:

  • Why in-cell DEL selection unlocks targets that purified-protein screens can't reach
  • How Portal delivers DEL constructs into HEK293 cytoplasm at ~100 nM
  • What's next: proximity-based selections against endogenous targets in live cell

  • Armon Sharei, Ph.D.

    Founder and CEO

  • Casey Krusemark

    Professor at Purdue University