- Why in-cell DEL selection unlocks targets that purified-protein screens can't reach
- How Portal delivers DEL constructs into HEK293 cytoplasm at ~100 nM
- What's next: proximity-based selections against endogenous targets in live cell
DNA-encoded chemical libraries are screened against purified protein outside of cells. Portal changes that — delivering full DEL constructs directly into the cytoplasm of live cells, so selections can run against targets in their native environment.
What You'll Learn:
Armon Sharei, Ph.D.
Founder and CEO
Casey Krusemark
Professor at Purdue University